liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Zfh1, a somatic motor neuron transcription factor, regulates axon exit from the CNS
Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Molecular genetics .
Show others and affiliations
2006 (English)In: Developmental Biology, ISSN 0012-1606, E-ISSN 1095-564X, Vol. 291, no 2, 253-263 p.Article in journal (Refereed) Published
Abstract [en]

Motor neurons are defined by their axon projections, which exit the CNS to innervate somatic or visceral musculature, yet remarkably little is known about how motor axons are programmed to exit the CNS. Here, we describe the role of the Drosophila Zfh1 transcription factor in promoting axon exit from the CNS. Zfh1 is detected in all embryonic somatic motor neurons, glia associated with the CNS surface and motor axons, and one identified interneuron. In zfh1 mutants, ventral projecting motor axons often stall at the edge of the CNS, failing to enter the muscle field, despite having normal motor neuron identity. Conversely, ectopic Zfh1 induces a subset of interneurons-all normally expressing two or more "ventral motor neuron transcription factors" (e.g. Islet, Hb9, Nkx6, Lim3)-to project laterally and exit the CNS. We conclude that Zfh1 is required for ventral motor axon exit from the CNS. © 2005 Elsevier Inc. All rights reserved.

Place, publisher, year, edition, pages
2006. Vol. 291, no 2, 253-263 p.
National Category
Natural Sciences
URN: urn:nbn:se:liu:diva-36203DOI: 10.1016/j.ydbio.2005.12.009Local ID: 30530OAI: diva2:257051
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2010-06-01

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Thor, Stefan
By organisation
The Institute of TechnologyMolecular genetics
In the same journal
Developmental Biology
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 54 hits
ReferencesLink to record
Permanent link

Direct link