Apoptotic cells at the crossroads of tolerance and immunity.
2005 (English)In: Role of Apoptosis in Infection / [ed] R.W. Compans, M.D. Cooper, T. Honjo, H. Koprowski, F. Melchers, M.B.A. Oldstone, S. Olsnes, M. Potter, P.K. Vogt, H. Wagner and Diane E. Griffin, Springer Berlin Heidelberg , 2005, Vol. 289, 259-292 p.Chapter in book (Other (popular science, discussion, etc.))
Clearance of apoptotic cells by phagocytes can result in either anti-inflammatory and immunosuppressive effects or prostimulatory consequences through presentation of cell-associated antigens to T cells. The differences in outcome are due to the conditions under which apoptosis is induced, the type of phagocytic cell, the nature of the receptors involved in apoptotic cell capture, and the milieu in which phagocytosis of apoptotic cells takes place. Preferential ligation of specific receptors on professional antigen-presenting cells dendriticc cells) has been proposed to induce potentially tolerogenic signals. On the other hand, dendritic cells can efficiently process and present antigens from pathogen-infected apoptotic cells to T cells. In this review, we discuss how apoptotic cells manipulate immunity through interactions with dendritic cells.
Place, publisher, year, edition, pages
Springer Berlin Heidelberg , 2005. Vol. 289, 259-292 p.
, Current Topics in Microbiology and Immunology, ISSN 0070-217X
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-36516DOI: 10.1007/b138916Local ID: 31479ISBN: 978-3-540-23006-9OAI: oai:DiVA.org:liu-36516DiVA: diva2:257364