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Development of a large titanium bone chamber to study in vivo bone ingrowth
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Orthopaedics and Sports Medicine. Östergötlands Läns Landsting, Orthopaedic Centre, Department of Orthopaedics Linköping.
2006 (English)In: Biomaterials, ISSN 0142-9612, Vol. 27, no 9, 1810-1816 p.Article in journal (Refereed) Published
Abstract [en]

In the bone conduction chamber (BCC) various materials and factors have been tested for their effect on bone graft incorporation and bone healing. However, biomaterials often have to be crushed to fit in this small chamber. Since cellular responses to biomaterials are influenced by the size and shape of particles, research concerning the evaluation of biomaterials is limited by the dimensions of this bone chamber. We enlarged and modified the BCC in order to be able to investigate the in vivo influences of biomaterials, growth factors and bone graft processing on tissue and bone ingrowth. Seven goats received four bone chambers each, three modified models and a BCC. The first model (BCC+) had two ingrowth openings, similar to that of the BCC. The second model had two round ingrowth openings (ROU). The third model had a open bottom for bone ingrowth (BOT). After 12 weeks, bone ingrowth distances were measured on histological sections and using μCT. Bone ingrowth was significantly higher (p=0.009 and 0.008) in the ROU compared to the BCC+ and the BOT, respectively. Similar results were found using μCT. The ROU model performed most similar to the BCC (gold standard) and is considered to be a promising new tool in biomaterials research. © 2005 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
2006. Vol. 27, no 9, 1810-1816 p.
Keyword [en]
Bone ingrowth; Bone remodelling; Histomorphometry; Image analysis; In vivo test
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-36577DOI: 10.1016/j.biomaterials.2005.11.005Local ID: 31664OAI: diva2:257426
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-11

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Aspenberg, Per
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Faculty of Health SciencesOrthopaedics and Sports MedicineDepartment of Orthopaedics Linköping
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