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Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Oncology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Pathology. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Pathology and Clinical Genetics.ORCID iD: 0000-0003-4075-159X
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Oncology. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Oncology UHL.
2006 (English)In: Cancer Letters, ISSN 0304-3835, E-ISSN 1872-7980, Vol. 231, no 1, 113-122 p.Article in journal (Refereed) Published
Abstract [en]

Resveratrol, a polyphenol found in grapes and wine, is considered a potential cancer chemopreventive agent. Resveratrol has been shown to induce transcription via both ERα and ERβ. We observed significantly lower tumor growth, decreased angiogenesis, and increased apoptotic index in ERα- ERβ+ MDA-MB-231 tumors in resveratrol-treated nude mice compared with controls. In vitro we found a significant increase in apoptosis in resveratrol-treated MDA-MB-231 cells in addition to significantly reduced extracellular levels of VEGF. This study supports the potential use of resveratrol as a chemotherapeutic agent in breast cancers. © 2005 Elsevier Ireland Ltd. All rights reserved.

Place, publisher, year, edition, pages
2006. Vol. 231, no 1, 113-122 p.
Keyword [en]
Angiogenesis; Apoptosis; MDA-MB-231; Vascular endothelial growth factor, VEGF
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-36627DOI: 10.1016/j.canlet.2005.01.031Local ID: 31928OAI: oai:DiVA.org:liu-36627DiVA: diva2:257476
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13

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Garvin, StinaÖllinger, KarinDabrosin, Charlotta

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