Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo
2006 (English)In: Cancer Letters, ISSN 0304-3835, Vol. 231, no 1, 113-122 p.Article in journal (Refereed) Published
Resveratrol, a polyphenol found in grapes and wine, is considered a potential cancer chemopreventive agent. Resveratrol has been shown to induce transcription via both ERα and ERβ. We observed significantly lower tumor growth, decreased angiogenesis, and increased apoptotic index in ERα- ERβ+ MDA-MB-231 tumors in resveratrol-treated nude mice compared with controls. In vitro we found a significant increase in apoptosis in resveratrol-treated MDA-MB-231 cells in addition to significantly reduced extracellular levels of VEGF. This study supports the potential use of resveratrol as a chemotherapeutic agent in breast cancers. © 2005 Elsevier Ireland Ltd. All rights reserved.
Place, publisher, year, edition, pages
2006. Vol. 231, no 1, 113-122 p.
Angiogenesis; Apoptosis; MDA-MB-231; Vascular endothelial growth factor, VEGF
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-36627DOI: 10.1016/j.canlet.2005.01.031Local ID: 31928OAI: oai:DiVA.org:liu-36627DiVA: diva2:257476