Randomized single versus double embryo transfer: Obstetric and paediatric outcome and a cost-effectiveness analysis
2006 (English)In: Human Reproduction, ISSN 0268-1161, Vol. 21, no 1, 210-216 p.Article in journal (Other academic) Published
Background: Transfer of several embryos after IVF results in a high multiple birth rate associated with increased morbidity and high costs for the neonatal care. In a previous randomized trial we demonstrated that a single embryo transfer (SET) strategy, including one fresh single embryo transfer and, if no live birth, one additional frozen-thawed SET, resulted in a live-birth rate that was not substantially lower than after double embryo transfer (DET) but markedly reduced the multiple birth rate. Methods: We compared costs for maternal health care and productivity losses and paediatric costs for the SET and DET strategies. In addition, maternal and paediatric outcomes between the two groups were compared. Results: The SET strategy resulted in lower average total costs from treatment until 6 months after delivery. There were a few more deliveries with at least one live-born child in the DET group. The incremental cost per extra delivery in the DET alternative was high, €71 940. The rates of prematurely born and low birthweight children were significantly lower with the SET strategy. There were also markedly fewer maternal and paediatric complications in the SET group. Conclusions: The SET strategy is superior to the DET strategy, when number of deliveries with at least one live-born child, incremental cost-effectiveness ratio and maternal and paediatric complications are taken into consideration. The findings do not support continuing transfers of two embryos in this group of patients. © The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.
Place, publisher, year, edition, pages
2006. Vol. 21, no 1, 210-216 p.
cost-effectiveness/IVF/multiple births/randomized controlled trial/single embryo transfer
National CategorySocial Sciences
IdentifiersURN: urn:nbn:se:liu:diva-36911DOI: 10.1093/humrep/dei298Local ID: 33027OAI: oai:DiVA.org:liu-36911DiVA: diva2:257760