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Biochemical Mathematical Modeling with Modelica and the BioChem Library
Linköping University, Department of Computer and Information Science. (PELAB)ORCID iD: 0000-0002-3435-4996
Faculty of Electrical Engineering, University of Ljubljana.
Linköping University, Department of Computer and Information Science. (PELAB)
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2007 (English)Conference paper (Refereed)
Abstract [en]

Considering the large amounts of data that is nowadays produced in the biochemistry (functional genomics) it is difficult to extract the information from the measurements. There is currently also a great interest in the development of novel analytical technologies for rapid screening of disease symptoms in pharmaceutical and clinical ap-plications. Modeling and simulation can provide a useful help in understanding the rela-tions of the measured substances and to minimize the need for measurements. The Bio-Chem library presented here is the first free Modelica library available for mathematical modeling of biochemical processes. Three examples are shown to illustrate the library. First, a simple insulin model is presented. Then a simplified model of cholesterol to-gether with simulations are shown. Next, a simple drug model together with parameter estimation in NONMEN are presented. The BioChem library allows for fast and end-user friendly modeling of biomedical systems. The graphical user interface provides graphics similar to that used in the description of metabolic pathways in biochemistry.

Place, publisher, year, edition, pages
Keyword [en]
cholesterol metabolic pathways, feedback control, functional ge
National Category
Computer Science
URN: urn:nbn:se:liu:diva-36983Local ID: 33194OAI: diva2:257832
Aplimaat 2007.
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2014-10-08

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Fritzson, PeterFransson, MartinGreen, Henrik
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