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Biochemical Mathematical Modeling with Modelica and the BioChem Library
Linköping University, Department of Computer and Information Science. (PELAB)ORCID iD: 0000-0002-3435-4996
Faculty of Electrical Engineering, University of Ljubljana.
Linköping University, Department of Computer and Information Science. (PELAB)
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2007 (English)Conference paper, Published paper (Refereed)
Abstract [en]

Considering the large amounts of data that is nowadays produced in the biochemistry (functional genomics) it is difficult to extract the information from the measurements. There is currently also a great interest in the development of novel analytical technologies for rapid screening of disease symptoms in pharmaceutical and clinical ap-plications. Modeling and simulation can provide a useful help in understanding the rela-tions of the measured substances and to minimize the need for measurements. The Bio-Chem library presented here is the first free Modelica library available for mathematical modeling of biochemical processes. Three examples are shown to illustrate the library. First, a simple insulin model is presented. Then a simplified model of cholesterol to-gether with simulations are shown. Next, a simple drug model together with parameter estimation in NONMEN are presented. The BioChem library allows for fast and end-user friendly modeling of biomedical systems. The graphical user interface provides graphics similar to that used in the description of metabolic pathways in biochemistry.

Place, publisher, year, edition, pages
2007.
Keyword [en]
cholesterol metabolic pathways, feedback control, functional ge
National Category
Computer Science
Identifiers
URN: urn:nbn:se:liu:diva-36983Local ID: 33194OAI: oai:DiVA.org:liu-36983DiVA: diva2:257832
Conference
Aplimaat 2007.
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2014-10-08

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Fritzson, PeterFransson, MartinGreen, Henrik

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