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p53 plays a central role in UVA and UVB induced cell damage and apoptosis in melanoma cells
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Division of dermatology and venereology.
2006 (English)In: Cancer Letters, ISSN 0304-3835, Vol. 244, no 2, 229-238 p.Article in journal (Refereed) Published
Abstract [en]

We investigated whether p53 plays a role in UV induced apoptosis in melanoma. UVA and UVB induced apoptosis in dose dependent and wild type p53 melanoma cells were much more vulnerable than the mutant cells, indicating that p53 played a role in UV-induced apoptosis in melanoma. No difference in p53 expression pattern between the primary and matched metastatic melanomas was noticed in tumour tissue or cell lines from the same patients. Our findings indicate that expression of p53 plays a role in UV-induced apoptosis in melanoma cells, but not important in melanoma progression from primary to metastasis. © 2006 Elsevier Ireland Ltd. All rights reserved.

Place, publisher, year, edition, pages
2006. Vol. 244, no 2, 229-238 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-36987DOI: 10.1016/j.canlet.2005.12.021Local ID: 33225OAI: diva2:257836
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-11

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Zhang, Hong
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