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Radiation-induced lysosomal iron reactivity: Implications for radioprotective therapy
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Pathology. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Respiratory Medicine UHL.
2006 (English)In: IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, ISSN 1521-6543, Vol. 58, no 7, 395-401 p.Article in journal (Refereed) Published
Abstract [en]

A novel mechanism of radiosensitization involves radiation-enhanced autophagy of damaged mitochondria and various metalloproteins, by which iron accumulates within lysosomes. Hydrogen peroxide, formed by the radiolytic cleavage of water, generates in the presence of lysosomal redox-active iron extremely reactive hydroxyl radicals by Fenton-type chemistry. Subsequent peroxidative damage of lysosomal membranes initiates release of harmful content from ruptured lysosomes that triggers a cascade of events eventuating in DNA damage and apoptotic or necrotic cell death. This article reviews the role of lysosomal destabilization in radiation-induced cell damage and death. The potential effects of iron chelation therapy targeted to the lysosomes for protection of normal tissues against unwanted effects by radiation is also discussed. © 2006 IUBMB.

Place, publisher, year, edition, pages
2006. Vol. 58, no 7, 395-401 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-37132DOI: 10.1080/15216540600755998Local ID: 33772OAI: diva2:257981
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-11

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Persson, Lennart
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Faculty of Health SciencesPathologyDepartment of Respiratory Medicine UHL
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