Radiation-induced lysosomal iron reactivity: Implications for radioprotective therapy
2006 (English)In: IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, ISSN 1521-6543, Vol. 58, no 7, 395-401 p.Article in journal (Refereed) Published
A novel mechanism of radiosensitization involves radiation-enhanced autophagy of damaged mitochondria and various metalloproteins, by which iron accumulates within lysosomes. Hydrogen peroxide, formed by the radiolytic cleavage of water, generates in the presence of lysosomal redox-active iron extremely reactive hydroxyl radicals by Fenton-type chemistry. Subsequent peroxidative damage of lysosomal membranes initiates release of harmful content from ruptured lysosomes that triggers a cascade of events eventuating in DNA damage and apoptotic or necrotic cell death. This article reviews the role of lysosomal destabilization in radiation-induced cell damage and death. The potential effects of iron chelation therapy targeted to the lysosomes for protection of normal tissues against unwanted effects by radiation is also discussed. © 2006 IUBMB.
Place, publisher, year, edition, pages
2006. Vol. 58, no 7, 395-401 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-37132DOI: 10.1080/15216540600755998Local ID: 33772OAI: oai:DiVA.org:liu-37132DiVA: diva2:257981