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Expression of Idiotypic Antibodies-1 and -2 and Breastfeeding in Relation to Antibody Levels Against Haemophilus Influenzae Type b in Children
Department of Paediatrics, Örebro University Hospital, Örebro and Department of Mothers' and Childrens' Health, Östersund Hospital, Östersund.
Biostatistics and Epidemiology, Örebro University Hospital, Örebro.
Department of Clinical Immunology, Göteborg University, Göteborg, Sweden; and Division of Medical Sciences, Northern Ontario School of Medicine, Lakehead University, Thunder Bay, Canada.
Department of Clinical Immunology, Göteborg University, Göteborg, Sweden.
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2006 (English)In: Scandinavian Journal of Immunology, ISSN 0300-9475, E-ISSN 1365-3083, Vol. 63, no 5, 371-375 p.Article in journal (Refereed) Published
Abstract [en]

The aim of the study was to determine the concentrations of serum antibodies against Haemophilus influenzae type b in preschool children in relation to the distribution of idiotypic antibodies 1 and 2 (Id-1 and Id-2) and the exposure to breastfeeding in infancy. Sera were obtained from 74 control children recruited in an earlier case-control study before the introduction of general Hib vaccination. Duration of breastfeeding was monitored, and prevalence of noninvasive infections was registered. Concentrations of IgG1 and IgG2 anti-Hib, as well as of total Id-1 and Id-2, were determined in ELISA. The expression of Id-1 antibodies increased with age in contrast to the Id-2 antibodies that were found only in children up to 24 months of age. Expression of Id-1 antibodies was positively correlated with higher anti-Hib levels of both the IgG1 and IgG2 isotype. Children expressing Id-2 antibodies showed higher IgG2 anti-Hib concentrations than those who did not have Id-2 (P = 0.001). The concentrations of neither Id-1 nor Id-2 antibodies were related to the duration of breastfeeding. Duration of breastfeeding was related to increased anti-Hib IgG2 in healthy children above 18 months of age. These study shows that the expression of idiotype-1 and idiotype-2 antibodies was associated with higher IgG2 anti-Hib concentration and that breastfeeding could enhance the anti-Hib IgG2 production in children.

Place, publisher, year, edition, pages
2006. Vol. 63, no 5, 371-375 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-37336DOI: 10.1111/j.1365-3083.2006.01746.xLocal ID: 34677OAI: diva2:258185
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2012-09-10Bibliographically approved

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Olcén, Per
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