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A single-nucleotide polymorphism in the XPG gene, and tumour stage, grade, and clinical course in patients with nonmuscle-invasive neoplasms of the urinary bladder
Karolinska Institutet.
Karolinska Institutet.
Karolinska Institutet.
Karolinska Institutet.
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2006 (English)In: BJU International, ISSN 1464-4096, E-ISSN 1464-410X, Vol. 97, no 4, 847-851 p.Article in journal (Refereed) Published
Abstract [en]

To evaluate whether the single nucleotide polymorphism (SNP), Asp1104His (G3507C), in the XPG gene affects malignant phenotypes of nonmuscle-invasive urinary bladder neoplasms (NIBN), by investigating associations between the SNP and clinicopathological variables in patients with NIBN.


The 233 patients constituted newly diagnosed cases of primary NIBN in the Stockholm area. The Asp1104His polymorphism in the XPG gene was genotyped using a polymerase chain reaction-restriction fragment length polymorphism technique.


The GC + CC genotypes were more frequent in stage pT1 tumours at initial diagnosis than pTa (odds ratio 1.9, 95% confidence interval 1.0–3.5, P = 0.048). The difference was larger in the young group (4.6, 1.9–11.8, P = 0.001). In the young group, the GC + CC genotypes were significantly more frequent in high-grade than in low-grade tumours (3.1, 1.5–6.8, P = 0.004) whereas in the older group the genotypes were less frequent in high-grade tumours (0.3, 0.1–0.7, P = 0.007). The XPG genotypes were not associated with tumour recurrence, stage progression or survival.


These results suggest that the SNP in the XPG gene might be related to tumour invasiveness in NIBN.

Place, publisher, year, edition, pages
2006. Vol. 97, no 4, 847-851 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-37613DOI: 10.1111/j.1464-410X.2005.05994.xLocal ID: 36707OAI: diva2:258462
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2010-05-19

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