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Excess mortality in incident cases of diabetes mellitus aged 15 to 34 years at diagnosis: A population-based study (DISS) in Sweden
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2006 (English)In: Diabetologia, ISSN 0012-186X, Vol. 49, no 4, 653-659 p.Article in journal (Refereed) Published
Abstract [en]

Aims/hypothesis: The objective of the study was to analyse the mortality, survival and cause of death patterns in incident cases of diabetes in the 15-34-year age group that were reported to the nationwide prospective Diabetes Incidence Study in Sweden (DISS). Methods: During the study period 1983-1999, 6,771 incident cases were reported. Identification of deaths was made by linking the records to the nationwide Cause of Death Register. Results: With an average follow-up of 8.5 years, resulting in 59,231 person-years, 159 deaths were identified. Diabetes was reported as the underlying cause of death in 51 patients (32%), and as a contributing cause of death in another 42 patients (26%). The standardised mortality ratio (SMR) was significantly elevated (RR=2.4, 95% CI: 2.0-2.8). The SMR was higher for patients classified by the reporting physician as having type 2 diabetes at diagnosis than for those classified as type 1 diabetic (2.9 and 1.8, respectively). Survival analysis showed significant differences in survival curves between males and females (p=0.0003) as well as between cases with different types of diabetes (p=0.005). This pattern was also reflected in the Cox regression model showing significantly increased hazard for males vs females (p=0.0002), and for type 2 vs type 1 (p=0.015) when controlling for age. Conclusions/ interpretation: This study shows a two-fold excess mortality in patients with type 1 diabetes and a three-fold excess mortality in patients with type 2 diabetes. Thus, despite advances in treatment, diabetes still carries an increased mortality in young adults, even in a country with a good economic and educational patient status and easy access to health care. © Springer-Verlag 2006.

Place, publisher, year, edition, pages
2006. Vol. 49, no 4, 653-659 p.
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Medical and Health Sciences
URN: urn:nbn:se:liu:diva-37792DOI: 10.1007/s00125-005-0135-xLocal ID: 38646OAI: diva2:258641
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-11

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Arnqvist, Hans
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Faculty of Health SciencesDivision of cell biologyDepartment of Endocrinology and Gastroenterology UHL
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