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High doses of OP-1 inhibit fibrous tissue ingrowth in impaction grafting
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Orthopaedics and Sports Medicine. Östergötlands Läns Landsting, Orthopaedic Centre, Department of Orthopaedics Linköping.
2006 (English)In: Clinical Orthopaedics and Related Research, ISSN 0009-921X, no 452, 250-259 p.Article in journal (Refereed) Published
Abstract [en]

A major concern in using growth factors in impaction grafting is the potential stimulation of the osteoclastic lineage. A solution would be using an osteoconductive material resistant to resorption and providing initial stability after reconstruction. Growth factors may promote bone formation in combination with such graft materials. We determined whether OP-1 would promote the incorporation of impacted morselized allografts and tricalcium phosphate/hydroxyapatite (TCP/HA) into host bone, whether bone formation would be preceded by an initial process of accelerated resorption, and whether the response to OP-1 remodeling/incorporation would be dose-related. We performed two bone chamber studies in goats to ascertain the early effects of OP-1 dose on resorption and incorporation of impacted morselized allografts and TCP/HA. After 4 weeks, the incorporation process of impacted morselized allografts and TCP/HA was not promoted by OP-1. We observed no signs of accelerated resorption preceding bone formation. An increase in OP-1 dose resulted in an inhibition of fibrous tissue formation but OP-1 did not promote bone formation. Early failures in impaction grafting, using mixes with OP-1, might be explained by the lack of fibrous tissue ingrowth and not by increased resorption and remodeling. © 2006 Lippincott Williams & Wilkins, Inc.

Place, publisher, year, edition, pages
2006. no 452, 250-259 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-37817DOI: 10.1097/01.blo.0000229340.18974.dcLocal ID: 39186OAI: diva2:258666
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-11

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Aspenberg, Per
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Faculty of Health SciencesOrthopaedics and Sports MedicineDepartment of Orthopaedics Linköping
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