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Editorial: Osteonecrosis of the jaw: What do bisphosphonates do?
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Orthopaedics and Sports Medicine. Östergötlands Läns Landsting, Orthopaedic Centre, Department of Orthopaedics Linköping.
2006 (English)In: Expert Opinion on Drug Safety, ISSN 1474-0338, E-ISSN 1744-764X, Vol. 5, no 6, 743-745 p.Article in journal, Editorial material (Other academic) Published
Abstract [en]

Osteonecrosis of the jaw is a new disease, partly caused by bisphosphonates. It is commonly assumed that the bisphosphonates somehow cause cell death (osteocyte necrosis) within the jawbone, which makes it prone to chronic infection. In this article, an alternative pathogenetic theory is suggested, based on the normal effect of bisphosphonates. According to the new theory, the bone is alive until it is injured and infected, and the reduced resorptive ability due to bisphosphonates hinders the formation of a fresh bone surface for re-establishment of bone cell coverage. The theories are compared, based on the recent, very scarce literature. None of them can be completely refuted, but the demonstration of living osteocytes within the lesion and the number of necessary assumptions speak against the theory of a primary, bisphosphonate-induced necrosis.

Place, publisher, year, edition, pages
2006. Vol. 5, no 6, 743-745 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-37819DOI: 10.1517/14740338.5.6.743Local ID: 39189OAI: diva2:258668
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2016-03-11Bibliographically approved

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Aspenberg, Per
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Faculty of Health SciencesOrthopaedics and Sports MedicineDepartment of Orthopaedics Linköping
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