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Vitamin D supplementation and diabetes-related autoimmunity in the ABIS study
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Linköping.
2007 (English)In: Pediatric Diabetes, ISSN 1399-543X, Vol. 8, no 1, 11-14 p.Article in journal (Refereed) Published
Abstract [en]

Supplementation with vitamin D during infancy, as well as intake of vitamin D during pregnancy, has been associated with decreased risk of type 1 diabetes or diabetes-related autoantibodies in children. The primary aim of this report was to investigate whether vitamin D supplementation during infancy is associated with diabetes-related autoimmunity at 1 and 2.5 yr in the children. Second, we examined whether consumption of vitamin-D-containing supplements during pregnancy is related to risk of autoimmunity in the offspring. Screening questionnaires were completed for 16 070 infants after delivery, including a food-frequency questionnaire regarding the mother's use of dietary supplements during pregnancy. Parents of 11 081 and 8805 infants completed a follow-up questionnaire regarding the use of vitamin supplementation at 1 and 2.5 yr, respectively. Autoantibodies against glutamic acid decarboxylase and islet antigen-2 (IA-2) were analyzed in whole blood from 8694 children at 1 yr and 7766 children at 2.5 yr. Supplementation with AD-drops was not associated with autoantibodies at 1 or 2.5 yr. Use of vitamin-D-containing supplements during pregnancy was associated with reduced diabetes-related autoimmunity at 1 yr (adjusted odds ratio: 0.707, confidence interval: 0.520-0.962, p = 0.028) but not at 2.5 yr. In conclusion, no association was found between an intermediate dose of vitamin D supplementation during infancy and development of diabetes-related autoantibodies at 1 and 2.5 yr. Use of vitamin-D-containing supplements during pregnancy was associated with reduced development.

Place, publisher, year, edition, pages
2007. Vol. 8, no 1, 11-14 p.
Keyword [en]
autoantibodies, infancy, pregnancy, type 1 diabetes, vitamin d supplementation
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-38344DOI: 10.1111/j.1399-5448.2006.00223.xLocal ID: 43774OAI: oai:DiVA.org:liu-38344DiVA: diva2:259193
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-11

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Ludvigsson, Johnny

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