liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Stronger synaptic connectivity as a mechanism behind development of working memory-related brain activity during childhood
Neuropediatric Resarch Unit KI.
Neuropediatric Research Unit KI.
Neuropediatric Resarch Unit KI.
Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Computational Biology .
Show others and affiliations
2007 (English)In: Journal of cognitive neuroscience, ISSN 0898-929X, Vol. 19, no 5, 750-760 p.Article in journal (Refereed) Published
Abstract [en]

The cellular maturational processes behind cognitive development during childhood, including the development of working memory capacity, are still unknown. By using the most standard computational model of visuospatial working memory, we investigated the consequences of cellular maturational processes, including myelination, synaptic strengthening, and synaptic pruning, on working memory-related brain activity and performance. We implemented five structural developmental changes occurring as a result of the cellular maturational processes in the biophysically based computational network model. The developmental changes in memory activity predicted from the simulations of the model were then compared to brain activity measured with functional magnetic resonance imaging in children and adults. We found that networks with stronger fronto-parietal synaptic connectivity between cells coding for similar stimuli, but not those with faster conduction, stronger connectivity within a region, or increased coding specificity, predict measured developmental increases in both working memory-related brain activity and in correlations of activity between regions. Stronger fronto-parietal synaptic connectivity between cells coding for similar stimuli was thus the only developmental process that accounted for the observed changes in brain activity associated with development of working memory during childhood. © 2007 Massachusetts Institute of Technology.

Place, publisher, year, edition, pages
2007. Vol. 19, no 5, 750-760 p.
National Category
Natural Sciences
URN: urn:nbn:se:liu:diva-38395DOI: 10.1162/jocn.2007.19.5.750Local ID: 44165OAI: diva2:259244
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-11

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Tegnér, Jesper
By organisation
The Institute of TechnologyComputational Biology
In the same journal
Journal of cognitive neuroscience
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 34 hits
ReferencesLink to record
Permanent link

Direct link