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Spectrophotometric analysis of melanocytic naevi during pregnancy
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Obstetrics and gynecology. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Gynecology and Obstetrics in Linköping.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Division of dermatology and venereology. Östergötlands Läns Landsting, Centre for Medicine, Department of Dermatology and Venerology in Östergötland.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Occupational and Environmental Medicine.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Division of dermatology and venereology. Östergötlands Läns Landsting, Centre for Medicine, Department of Dermatology and Venerology in Östergötland.
2007 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, Vol. 87, no 3, 231-237 p.Article in journal (Refereed) Published
Abstract [en]

Malignant melanoma is the most common cancer during pregnancy, but it is unknown whether melanocytic naevi in general are activated. A total of 381 melanocytic naevi in 34 Caucasian primigravidae were examined using spectrophotometric intracutaneous analysis (SIAscopy) technology in early pregnancy and prior to delivery. The Siagraphs of each naevus were then compared in order to evaluate changes over time. A total of 163 melanocytic naevi in 21 nulliparous women served as an additional control group. At the first visit none of the Siagraphs examined for the case or control groups aroused suspicion of dysplastic naevus or melanoma and no significant structural changes were noted during the observation period. However, 2.1% of the melanocytic naevi in the pregnant group increased and 1.3% decreased in size. Corresponding figures in the non-pregnant group were 1.8% and 0%, respectively. Only one naevus in a pregnant woman increased slightly in epidermal pigmentation, and a decrease in pigmentation was noted in 3.7% of the melanocytic naevi in the cases and 1.8% in the controls. None of the differences within or between the groups was statistically significant. We conclude that pregnancy does not influence the appearance of pigmented naevi. A changing naevus during pregnancy should be examined carefully and considered for excision and histopathology. © 2007 Acta Dermato-Venereologica.

Place, publisher, year, edition, pages
2007. Vol. 87, no 3, 231-237 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-39204DOI: 10.2340/00015555-0227Local ID: 47231OAI: oai:DiVA.org:liu-39204DiVA: diva2:260053
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-11

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Wyon, YvonneSynnerstad, IngridFredrikson, MatsRosdahl, Inger

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Faculty of Health SciencesObstetrics and gynecologyDepartment of Gynecology and Obstetrics in LinköpingDivision of dermatology and venereologyDepartment of Dermatology and Venerology in ÖstergötlandOccupational and Environmental Medicine
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