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Assessing dose-response relationships by cumulative exposures in epidemiological studies
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Occupational and Environmental Medicine. Östergötlands Läns Landsting, Pain and Occupational Centre, Occupational and Environmental Medicine Centre.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Occupational and Environmental Medicine.
2007 (English)In: American Journal of Industrial Medicine, ISSN 0271-3586, Vol. 50, no 3, 217-220 p.Article in journal (Refereed) Published
Abstract [en]

Background: If the occurrence of disease monotonically increases with the degree of exposure in an epidemiologic study, a dose-response (or exposure-response) relationship is indicated and facilitates the interpretation that the exposure has a causal role. It is not uncommon, however, that there is some effect in terms of an overall increased relative risk but no clear dose-response relationship. Methods: Models presented here show that cumulative exposure, as involving the duration of exposure, is not an adequate parameter when more recent exposure or the intensity of the exposure plays the greater role for the disease outcome. Conclusions: In lack of a dose-response pattern by cumulative exposure, the interpretation of an overall increased risk might well be that there is no definite effect. The proper consideration should be, however, that the measure of exposure could be inadequate, suggesting a need for further analyses and evaluations of the material studied. © 2007 Wiley-Liss, Inc.

Place, publisher, year, edition, pages
2007. Vol. 50, no 3, 217-220 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-39215DOI: 10.1002/ajim.20377Local ID: 47328OAI: oai:DiVA.org:liu-39215DiVA: diva2:260064
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-11

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Axelson, OlavFredrikson, Mats

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