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Gut microflora associated characteristics in first-degree relatives of children with celiac disease
Dept of Microbiology KS, Stockholm.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Norrköping.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Norrköping.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Linköping.
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2007 (English)In: Scandinavian Journal of Gastroenterology, ISSN 0036-5521, E-ISSN 1502-7708, Vol. 42, no 10, 1204-1208 p.Article in journal (Refereed) Published
Abstract [en]

Objective. In celiac disease (CD), enteropathy of the small bowel results from a T-cell-mediated reaction to gluten in the diet. In addition to gluten, other environmental and genetic factors participate in the disease pathogenesis. We have recently reported the finding of a significantly different short-chain fatty acid (SCFA) profile in fecal samples from children with CD compared to healthy controls reflecting an aberrant gut microflora. The aim of the present study was to make a functional evaluation of the gut microflora status in non-celiac 1st degree relatives of children with CD. Material and methods. Fecal samples from 76 symptom-free, non-celiac, 1st degree CD relatives and from 91 aged-matched healthy controls were analyzed for fecal tryptic activity (FTA) and a number of SCFAs. Results. There was a significantly lower level of acetic acid and total SCFAs as well as a significantly increased level of i-butyric acid and FTA in relatives compared to healthy controls. Conclusions. The FTA and the SCFA profiles in fecal samples from 1st degree relatives of children with CD are different from those of healthy individuals. The implication of this observation provides insight into the pathogenesis of CD and opens up the possibility of future new diagnostic, therapeutic and prophylactic strategies. © 2007 Taylor & Francis.

Place, publisher, year, edition, pages
2007. Vol. 42, no 10, 1204-1208 p.
Keyword [en]
Celiac disease, fecal microflora, fecal tryptic activity relatives, short-chain fatty acids
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-39407DOI: 10.1080/00365520701320687Local ID: 48247OAI: oai:DiVA.org:liu-39407DiVA: diva2:260256
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13

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Stenhammar, LarsHögberg, LottaFälth-Magnusson, KarinMagnusson, Karl-EricSundqvist, Tommy

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Stenhammar, LarsHögberg, LottaFälth-Magnusson, KarinMagnusson, Karl-EricSundqvist, Tommy
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Faculty of Health SciencesPediatricsDepartment of Paediatrics in NorrköpingDepartment of Paediatrics in LinköpingMedical Microbiology
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