Seasonal variation in the diagnosis of type 1 diabetes in south-east Sweden
2007 (English)In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 76, no 1, 75-81 p.Article in journal (Refereed) Published
With the aim to survey the seasonal pattern of diagnosis of type 1 diabetes we included all 1903 children <16 years of age and who had been diagnosed with type 1 diabetes between 1977 and 2001 in the south-east of Sweden. To investigate the seasonal pattern a mixture of two cosine functions was included in a logistic regression model.
There was a clear seasonal variation over the years (p < 0.001). Children in the oldest age group (11–15 years) showed the most obvious seasonal variation (p < 0.001). Children with a short duration of symptoms had about the same seasonal variation as children with a long duration. Both children with and without an infection 3 months prior to diagnosis showed significant seasonal variation (p < 0.001) although the seasonal pattern differed between the two groups (p < 0.001). As the incidence of diabetes increased during the 25 years the study period was divided into periods of 5 years and it was only during the two last periods that significant seasonal variation occurred.
There is a clear seasonal variation in diagnosis of type 1 diagnosis in children and the results suggest that children with a less aggressive disease process at diagnosis were most responsible for this variation. Children with and without prior infection showed a different seasonal pattern.
Place, publisher, year, edition, pages
2007. Vol. 76, no 1, 75-81 p.
Type 1 diabetes, seasonality, pH-value, infection, duration of symptoms
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-39415DOI: 10.1016/j.diabres.2006.07.023Local ID: 48271OAI: oai:DiVA.org:liu-39415DiVA: diva2:260264