Pathophysiological mechanisms in chronic musculoskeletal pain (fibromyalgia): the role of central and peripheral sensitization and pain disinhibition
2007 (English)In: Baillière's Best Practice & Research: Clinical Rheumatology, ISSN 1521-6942, Vol. 21, no 3, 465-480 p.Article in journal (Refereed) Published
Chronic musculoskeletal pain has biological, psychological and social components. This review deals with the biological factors, with emphasis on the fibromyalgia syndrome (FMS). Studies on central sensitization of pain-transmitting neurons, changes in endogenous pain modulation that give rise to pain disinhibition, referred pain, pain-related decrease in muscle strength and endurance, and pain generators in deep tissues are reviewed. In FMS there is strong scientific support for the statement that the biological part of the syndrome is a longstanding or permanent change in the function of the nociceptive nervous system that can be equated with a disease. Further research is necessary in order to determine which methods are best for diagnosis of the pain hypersensitivity in clinical practice. FMS may be the far end of a continuum that starts with chronic localized/regional musculoskeletal pain and ends with widespread chronic disabling pain. © 2007 Elsevier Ltd. All rights reserved.
Place, publisher, year, edition, pages
2007. Vol. 21, no 3, 465-480 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-39519DOI: 10.1016/j.berh.2007.03.007Local ID: 49227OAI: oai:DiVA.org:liu-39519DiVA: diva2:260368