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Cerebrospinal fluid kynurenic acid in male patients with schizophrenia - Correlation with monoamine metabolites
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Psychiatry. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Psychiatry.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Psychiatry. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Psychiatry.
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2007 (English)In: Acta Neuropsychiatrica, ISSN 0924-2708, E-ISSN 1601-5215, Vol. 19, no 1, 45-52 p.Article in journal (Refereed) Published
Abstract [en]

Background: The tryptophan metabolite kynurenic acid (KYNA) is an endogenous glutamate/nicotinic receptor antagonist. Previous studies have shown that the concentration of the compound is increased in cerebrospinal fluid (CSF) of patients with schizophrenia. Furthermore, it has been found that the CSF concentration of KYNA is positively correlated to CSF concentrations of the monoamine metabolites homovanillic acid (HVA) and 5-hydroxy indoleacetic acid (5-HIAA) in healthy control subjects. Objectives: To study the correlations between KYNA and the monoamine metabolites HVA, 5-HIAA and 4-hydroxy-3- methoxyphenylglycol (HMPG) in CSF of male patients (n = 53, ranging from 20 to 48 years of age) with verified schizophrenia. Methods: CSF was obtained by lumbar puncture, and KYNA analysis was performed with an isocratic reversed-phase high-performance liquid chromatography system connected to a fluorescence detector. HVA, 5-HIAA and HMPG concentrations were measured by mass fragmentography with deuterium-labelled internal standards. Results: Positive intercorrelations were found between CSF KYNA, HVA and 5-HIAA, while CSF content of HMPG did not correlate to KYNA or any of the monoamine metabolites in CSF. Conclusion: The results of this study suggest that increased KYNA formation is associated with an increased dopamine and serotonin turnover in male patients with schizophrenia. © 2007 Blackwell Munksgaard.

Place, publisher, year, edition, pages
2007. Vol. 19, no 1, 45-52 p.
Keyword [en]
Homovanillic acid (HVA); 5-hydroxy-indoleacetic acid (5-HIAA); 4-hydroxy-3-methoxyphenylglycol (HMPG), human
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-39546DOI: 10.1111/j.1601-5215.2006.00170.xLocal ID: 49628OAI: oai:DiVA.org:liu-39546DiVA: diva2:260395
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13

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Nordin, ConnySkogh, Elisabeth

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