Cooling of the urinary bladder activates neurons in the dorsal horn of the spinal cord
2004 (English)In: NeuroReport, ISSN 0959-4965, Vol. 15, no 2, 351-355 p.Article in journal (Refereed) Published
Although visceral innocuous cold receptors have been documented, the central termination of their afferents is unknown. We used menthol solution (0. 6 m M) to obtain selective activation of cold receptors in the urinary bladder of rats. Innocuous cold stimulation induced Fos expression in a population of neurons in the superficial dorsal horn of L6-SI segments of the spinal cord. Neurons in other regions of the spinal cord, e.g. the lumbar parasympathetic nucleus or the dorsal commissure region, were activated to a similar degree by menthol and control infusions, indicating a response to bladder filling. Our results are consistent with the proposal that subsets of modality-specific dorsal horn neurons convey specific information regarding the exteroceptive and interoceptive state of the animal. © 2004 Lippincott Williams & Wilkins.
Place, publisher, year, edition, pages
2004. Vol. 15, no 2, 351-355 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-39569DOI: 10.1097/00001756-200402090-00028Local ID: 49792OAI: oai:DiVA.org:liu-39569DiVA: diva2:260418