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Testosterone correlated to symptoms of partial androgen deficiency in aging men (PADAM) in an elderly Swedish population
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Obstetrics and gynecology. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Gynecology and Obstetrics in Linköping.
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2007 (English)In: Menopause: The Journal of the North American Menopause, ISSN 1072-3714, E-ISSN 1530-0374, Vol. 14, no 6, 999-1005 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To investigate the prevalence of different symptoms of partial androgen deficiency in aging men (PADAM) and to correlate them with blood concentrations of testosterone and bioavailable testosterone. DESIGN: A total of 370 men, aged 55 to 75 years, were invited to one of three primary healthcare centers in Sweden. They were asked to complete a questionnaire regarding demographic data, medical history, mood status, medication, castration therapy and smoking, exercise and alcohol habits, as well as different symptoms of PADAM. The 10 questions from a previously used questionnaire (the ADAM questionnaire) were included. The men were offered blood tests for analyses of testosterone, follicle stimulating hormone, luteinizing hormone, steroid hormone-binding globulin, and albumin. From these test results, we calculated the bioavailable testosterone. RESULTS: Of the questionnaires sent out, 81.6% were returned and eligible for evaluation. Blood samples were obtained from 85.8% of men answering the questionnaire. Many of the symptoms, including five from the ADAM questionnaire, were more common in older age groups (P < 0.05). Three symptoms, deterioration in work performance, decreased strength and/or endurance, and bothersome hot flushes, were associated with low bioavailable testosterone and/or testosterone (P < 0.05). Testosterone and bioavailable testosterone did not differ between age groups, but bioavailable testosterone was higher in men with three or fewer symptoms on the ADAM questionnaire. CONCLUSIONS: Symptoms associated with PADAM often occur in an elderly population, but we could only find an association between three symptoms and blood testosterone concentrations, one being bothersome hot flushes. It is likely that these symptoms have a more complex background than only PADAM. ©2007The North American Menopause Society.

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2007. Vol. 14, no 6, 999-1005 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-39805DOI: 10.1097/gme.0b013e318057786bLocal ID: 51314OAI: oai:DiVA.org:liu-39805DiVA: diva2:260654
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13

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Spetz, Anna-ClaraTheodorsson, ElvarHammar, Mats

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Spetz, Anna-ClaraTheodorsson, ElvarHammar, Mats
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Faculty of Health SciencesObstetrics and gynecologyDepartment of Gynecology and Obstetrics in LinköpingDivision of clinical chemistryDepartment of Clinical Chemistry
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Menopause: The Journal of the North American Menopause
Medical and Health Sciences

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