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Preoperative interleukin-6 production by mononuclear blood cells predicts survival after radical surgery for colorectal carcinoma
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Division of surgery. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Surgery in Östergötland.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery.
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2007 (English)In: Cancer, ISSN 0008-543X, E-ISSN 1097-0142, Vol. 109, no 9, 1742-1749 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND. Colorectal cancer is one of the most common forms of cancer in the Western world. Staging based on histopathology is currently the most accurate predictor of outcome after surgery. Colorectal cancer is curable if treated at an early stage (stage I-III). However, for tumors in stages II and III there is a great need for tests giving more accurate prognostic information defining the patient population in need of closer follow-up and/or adjuvant therapy. Furthermore, tests that provide prognostic information preoperatively could provide a guide both for preoperative oncologic treatment and the surgical procedure. METHODS. Peripheral blood mononuclear cells (PBMCs) were isolated preoperatively, within a week before primary surgery, from 39 patients undergoing surgery for colorectal cancer. The PBMCs were cultured in vitro for 24 hours in the presence of autologous serum and lipopolysaccharide (LPS). Interleukin-6 (IL-6) production was measured with enzyme-linked immunosorbent assay (ELISA). Staging based on histopathology was performed in all patients. Patients were followed for at least 54 months. RESULTS. A production of >5000 pg/mL of IL-6 identified colorectal cancer patients with a poor prognosis. Eight out of 13 patients with >5000 pg/mL IL-6 died from cancer within the follow-up period, whereas no cancer-related deaths were recorded among 21 patients with 5000 pg/mL IL-6 or less. A multivariate Cox regression analysis, stratified for T- and N-stage, identified IL-6 production as an independent prognostic factor. CONCLUSIONS. IL-6 production in vitro by PBMC can predict survival after radical surgery for colorectal cancer. © 2007 American Cancer Society.

Place, publisher, year, edition, pages
2007. Vol. 109, no 9, 1742-1749 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-39824DOI: 10.1002/cncr.22623Local ID: 51413OAI: oai:DiVA.org:liu-39824DiVA: diva2:260673
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13

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Clinchy, BirgittaDruvefors, PelleHellsten, AnnaHåkansson, AnnikaGustafsson, BertilSjödahl, Rune

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Clinchy, BirgittaDruvefors, PelleHellsten, AnnaHåkansson, AnnikaGustafsson, BertilSjödahl, Rune
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Faculty of Health SciencesDepartment of Biomedicine and SurgeryDivision of surgeryDepartment of Surgery in ÖstergötlandOncologyDepartment of Oncology UHLPathologyDepartment of Clinical Pathology and Clinical Genetics
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