liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Pain sensations to the cold pressor test in normally menstruating women: Comparison with men and relation to menstrual phase and serum sex steroid levels
Linköping University, Department of Biomedicine and Surgery. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Computer and Information Science, Statistics. Linköping University, Faculty of Arts and Sciences.
Linköping University, Department of Social and Welfare Studies. Linköping University, Faculty of Health Sciences.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Obstetrics and gynecology. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Gynecology and Obstetrics in Linköping.
Show others and affiliations
2007 (English)In: American Journal of Physiology. Regulatory Integrative and Comparative Physiology, ISSN 0363-6119, E-ISSN 1522-1490, Vol. 293, no 4Article in journal (Refereed) Published
Abstract [en]

The role of gonadal hormones on pain sensations was investigated in normally menstruating women (n = 16) using the cold pressor test. Tolerance time, pain threshold, and pain intensity were examined once a week during a 4-wk period, and serum concentrations of 17β-estradiol and progesterone were determined at each test session, which were classified into the early follicular phase, late follicular phase, early luteal phase, and late luteal phase, as determined by the first day of menses and the actual hormone levels recorded. A group of men (n = 10) of the same age interval was examined for comparison. The data show that pain threshold was reduced during the late luteal phase compared with the late follicular phase, and hormone analyses showed significant positive correlation between the progesterone concentration and lowered pain threshold and increasing pain intensity. Hormone analysis also showed an interaction between S-estradiol and S-progesterone on pain intensity, demonstrating that the increased perceived pain intensity that was associated with high progesterone concentrations was significantly reduced with increasing levels of estradiol. While no statistically significant sex differences in pain measurements were found, women displayed much more pronounced, and statistically significant, session-to-session effects than men, with increased pain threshold and decreased pain intensity with each test session. Hence, these data suggest that the changes in the serum concentration of gonadal hormones that occur during the menstrual cycle influence pain sensations elicited by noxious tonic cold stimulation and show that adaptation to the cold pressor test may be sex dependent. © 2007 the American Physiological Society.

Place, publisher, year, edition, pages
2007. Vol. 293, no 4
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-39946DOI: 10.1152/ajpregu.00127.2007Local ID: 51815OAI: oai:DiVA.org:liu-39946DiVA: diva2:260795
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13Bibliographically approved
In thesis
1. The effect of gonadal hormones on the sensation of pain: Quantitative sensory testing in women
Open this publication in new window or tab >>The effect of gonadal hormones on the sensation of pain: Quantitative sensory testing in women
2011 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Accumulating evidence points to sex differences in pain sensitivity and many chronic pain conditions preferentially affect women. Sex hormones, and in particular estrogens, have been shown to affect pain processing and pain sensitivity in animals, although the findings are divergent. The aim of the research on which this thesis is based was to examine the effect of gonadal hormones on the sensation of pain in women who either presented normal variations in hormonal levels over time or who had been given hormone treatment.

Different quantitative sensory tests (QST) examining temperature thresholds, cold, heat and pressure pain thresholds, as well as tolerance thresholds for heat and cold, were performed during different hormonal conditions: During hormonal fluctuations throughout the ovulatory cycle (papers I, II); in women undergoing in vitro fertilization (IVF), a treatment associated with extremely low and high 17β-estradiol levels (paper III); and before and after hormonal substitution treatment in postmenopausal women suffering from fibromyalgia (paper IV).

The results showed little changes in pain sensitivity during the ovulatory cycle, with an interaction between 17β-estradiol and progesterone on cold pressor pain as the major finding. No significant changes in pain sensitivity were seen even with the extreme variations in 17β-estradiol levels that occurred during the IVF-treatment. Also, the use of hormonal substitution treatment did not affect pain thresholds or tolerance in postmenopausal women suffering from fibromyalgia.

Session-to-session effects were reported in several studies and seem to be an important factor when using repeated sessions design. Additionally, the present work also emphasizes the use of actual hormonal values as essential instead of tentative calendar methods when evaluating hormonal effects on the sensation of pain during the menstrual cycle. 

The present studies thus indicate that changes in gonadal hormone levels have little effect on experimental pain in women, contrary to what has been reported in animal studies.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2011. 84 p.
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1258
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-71210 (URN)978-91-7393-079-6 (ISBN)
Public defence
2011-11-30, Berzeliussalen, Hälsouniversitetet, Campus US, Linköpings universitet, Linköping, 13:00 (Swedish)
Opponent
Supervisors
Available from: 2011-11-08 Created: 2011-10-06 Last updated: 2011-11-08Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Authority records BETA

Stening, KentEriksson, OlleWahren, Lis KarinBerg, GöranHammar, MatsBlomqvist, Anders

Search in DiVA

By author/editor
Stening, KentEriksson, OlleWahren, Lis KarinBerg, GöranHammar, MatsBlomqvist, Anders
By organisation
Department of Biomedicine and SurgeryFaculty of Health SciencesStatisticsFaculty of Arts and SciencesDepartment of Social and Welfare StudiesObstetrics and gynecologyDepartment of Gynecology and Obstetrics in LinköpingDivision of cell biology
In the same journal
American Journal of Physiology. Regulatory Integrative and Comparative Physiology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 197 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf