liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Critical role of FLT3 ligand in IL-7 receptor-independent T lymphopoiesis and regulation of lymphoid-primed multipotent progenitors
Lund University.
Lund University.
Lund University.
Malmö University Hospital.
Show others and affiliations
2007 (English)In: Blood, ISSN 0006-4971, E-ISSN 1528-0020, Vol. 110, no 8, 2955-2964 p.Article in journal (Refereed) Published
Abstract [en]

The molecular pathways regulating lymphoid priming, fate, and development of multipotent bone marrow (BM) stem/progenitor cells that continuously replace thymic progenitors remain largely unknown. Herein, we show that fms-like tyrosine kinase 3 (Flt3) ligand (Fl)–deficient mice have distinct reductions in the earliest thymic progenitors in fetal, postnatal, and adult thymus. A critical role of FL in thymopoiesis was particularly evident in the absence of interleukin-7 receptor (IL-7R) signaling. Fl–/–Il-7r–/– mice have extensive reductions in fetal and postnatal thymic progenitors that result in a loss of active thymopoiesis in adult mice, demonstrating an indispensable role of FL in IL-7R–independent fetal and adult T lymphopoiesis. Moreover, we establish a unique and critical role of FL, distinct from that of IL-7R, in regulation of the earliest lineage-negative (Lin) LinSCA1+KIT+ (LSK) FLT3hi lymphoid-primed multipotent progenitors in BM, demonstrating a key role of FLT3 signaling in regulating the very earliest stages of lymphoid progenitors.

Place, publisher, year, edition, pages
2007. Vol. 110, no 8, 2955-2964 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-39976DOI: 10.1182/blood-2006-10-054726Local ID: 51895OAI: diva2:260825
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2010-05-19

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Sigvardsson, Mikael
In the same journal
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 23 hits
ReferencesLink to record
Permanent link

Direct link