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Overexpression of connective tissue growth factor WISP-1 in Chinese primary rectal cancer patients
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Oncology. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Oncology UHL.
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2007 (English)In: World Journal of Gastroenterology, ISSN 1007-9327, Vol. 13, no 28, 3878-3882 p.Article in journal (Refereed) Published
Abstract [en]

Aim: To clarify the expression change of Wnt-induced secreted protein-1 (WISP-1) in human rectal cancer and to determine whether it is correlated with invasion and metastasis of human rectal cancer. Methods: Eighty-six paired samples of rectal cancer and surgically resected distant normal rectal tissue were collected and allocated into cancer group and control group respectively. WISP-1 mRNA was detected by relative quantitative real-time RT-PCR and WISP-1 protein was examined by immunohistochemical staining. Results: WISP-1 gene overexpression was found in 65% (56/86) primary rectal cancers, 2-30 times that of the level in normal matched rectal tissues (P = 0.001). The mRNA expression level was correlated with Duke's staging, histological differentiation grade and lymph node status. The WISP-1 protein expression was in accordance with mRNA expression level. The positive degree of immunohistochemical staining in the cancer group (1.40 ± 0.35) was different from that in control group (1.04 ± 0.08, P < 0.001). Moreover, in cancer group the positive staining degree in high-level mRNA cancers (1.46 ± 0.37, n = 56) was higher than that in low-level mRNA (1.28 ± 0.28, n = 30, P = 0.018). Conclusion: Aberrant levels of WISP-1 expression may play a role in rectal tumorigenesis. WISP-1 may be used as a specific clinical diagnosis and prognosis marker in rectal cancer. © 2007 WJG. All rights reserved.

Place, publisher, year, edition, pages
2007. Vol. 13, no 28, 3878-3882 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-40003Local ID: 52013OAI: diva2:260852
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-11

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Sun, Xiao-Feng
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Faculty of Health SciencesOncologyDepartment of Oncology UHL
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