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Association of NFKBIA polymorphism with colorectal cancer risk and prognosis in Swedish and Chinese populations
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Oncology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Oncology.
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2007 (English)In: Scandinavian Journal of Gastroenterology, ISSN 0036-5521, Vol. 42, no 3, 345-350 p.Article in journal (Refereed) Published
Abstract [en]

Objective. The inhibitory proteins, IκBs, regulate the activity of nuclear factor kappa-beta (NF-κB), which is implicated in tumorigenesis by regulating expression of a variety of genes involved in cellular transformation, proliferation, invasion, angiogenesis and metastasis. Variants in the genes encoding IκBs may be involved in cancer development through the activation of NF-κB. The objective of this study was to investigate the susceptibility of an A to G variation (rs696) in the 3′ UTR of NFKBIA (encoding IκBα) to colorectal cancer (CRC) and the association of this polymorphism with clinicopathologic variables in CRC patients. Material and methods. A case-control study was carried out on a Swedish (155 CRCs, 438 controls) and a Chinese population (199 CRCs, 577 controls). The genotype of NFKBIA was determined by PCR-restriction fragment length polymorphism. Results. The frequency of the AG genotype was increased in the Chinese patients ≥50 years of age compared with the Chinese controls (odds ratio (OR) = 3.06, 95% confidence interval (CI) = 1.55-6.02, p=0.001), even when adjusted for age (OR = 3.20, 95% CI = 1.61-6.38, p=0.001). The GG genotype of NFKBIA was related to a poorer survival rate in the Swedish patients, independent of gender, age, tumour location, Dukes' stage and differentiation (hazard ratio = 3.10, 95% Cl = 1.28-7.60, p=0.01). Conclusions. Chinese individuals ≥50 years of age carrying the AG genotype of NFKBIA may be at an increased risk of developing CRC, and the GG genotype of NFKBIA may be considered as a prognostic factor for Swedish CRC patients. © 2007 Taylor & Francis.

Place, publisher, year, edition, pages
2007. Vol. 42, no 3, 345-350 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-40004DOI: 10.1080/00365520600880856Local ID: 52014OAI: diva2:260853
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-11

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Gao, JingfangPfeifer, DaniellaArbman, GunnarCarstensen, JohnSun, Xiao-Feng
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Faculty of Health SciencesOncologyDivision of surgeryDepartment of Surgery in ÖstergötlandFaculty of Arts and SciencesTema Health and SocietyDepartment of Oncology UHL
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Scandinavian Journal of Gastroenterology
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