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Expression of MAC30 protein is related to survival and biological variables in primary and metastatic colorectal cancers
Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Division of surgery. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Surgery in Östergötland.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Oncology.
General Surgery, University of Heidelberg, Heidelberg, Germany.
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2007 (English)In: International Journal of Oncology, ISSN 1019-6439, Vol. 30, no 1, 91-95 p.Article in journal (Refereed) Published
Abstract [en]

MAC30 is highly expressed in several types of tumors including colorectal cancers, however, its clinicopathological and biological significance in colorectal cancers is currently not known. The aim of our study was to investigate MAC30 expression in distant normal mucosa, adjacent normal mucosa, primary tumors and metastases of colorectal cancer, and to determine the relationship between MAC30 expression and clinicopathological and biological variables. MAC30 expression was immunohistochemically examined in distant normal mucosa (n = 54), adjacent normal mucosa (n = 123), primary tumors (n = 217) and lymph node metastases (n = 56) from colorectal cancer patients. MAC30 cytoplasmic expression was increased from distant normal mucosa to primary tumor and to metastasis (p < 0.0001-0.04). Furthermore, 40% primary and 37% metastatic tumors showed stronger cytoplasmic expression of MAC30 at the tumor invasive margins compared to inner tumor areas. Strong cytoplasmic expression of MAC30 in the metastasis was related to a poor prognosis (p = 0.04). MAC30 cytoplasmic expression was positively related to expression of proliferating cell nuclear antigen (p = 0.04), p53 (p = 0.04), nucleoporin 88 (p = 0.001), legumain (p = 0.004) and particularly interesting new cysteine-histidine rich protein (p = 0.004). However, MAC30 expression in the nucleus and stroma did not have any clinicopathological and biological significance (p > 0.05). In conclusion, MAC30 protein may play a role in development of colorectal cancer, and can be considered as a prognostic factor.

Place, publisher, year, edition, pages
2007. Vol. 30, no 1, 91-95 p.
Keyword [en]
colorectal cancer, MAC30 expression, metastasis, prognosis, survival rate
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-40008Local ID: 52018OAI: diva2:260857
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2009-11-10

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Moparhti, Satish BabuArbman, GunnarWallin, ÅsaSun, Xiao-Feng
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Department of Physics, Chemistry and BiologyThe Institute of TechnologyFaculty of Health SciencesDivision of surgeryDepartment of Surgery in ÖstergötlandOncologyDepartment of Oncology UHL
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International Journal of Oncology
Medical and Health Sciences

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