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Continuous insulin infusion (CSII) or modern type of multiple daily injections (MDI) in diabetic children and adolescents a critical review on a controversial issue
Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping.
Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping.
2007 (English)In: Pediatric Endocrinology Reviews: diabetes, nutrition, metabolism, ISSN 1565-4753, Vol. 5, no 2, 666-678 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE:

There is a common opinion that CSII is superior to MDI. CSII offers the most physiological insulin substitution.

METHOD:

Review of recent publications (Cochrane criteria), on modern multiple daily injections (MDI) based on insulin analogues, modern self-control and education.

RESULTS:

There is a lack of randomised controlled studies comparing CSII with modern MDI in children and adolescents. In some studies CSII seems to give a slight decrease of HbA1c, a slightly better quality of life, perhaps less hypoglycemia. However, serious hypoglycemia, sometimes fatal, occurs, DKA seems to increase, weight gain and local infections at injection sites may occur and CSII is more expensive than MDI.

CONCLUSION:

CSII is a useful tool. It is reasonable to use it when there are appropriate indications. CSII does not solve all problems but has to be combined with other important parts of diabetes treatment.

Place, publisher, year, edition, pages
2007. Vol. 5, no 2, 666-678 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-40308PubMedID: 18084161Local ID: 52899OAI: oai:DiVA.org:liu-40308DiVA: diva2:261157
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2014-09-02Bibliographically approved

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Ludvigsson, JohnnySamuelsson, Ulf

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CiteExportLink to record
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