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NFKB and NFKBI polymorphisms in relation to susceptibility of tumour and other diseases
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Oncology. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Oncology UHL.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Division of dermatology and venereology.
2007 (English)In: Histology and Histopathology, ISSN 0213-3911, Vol. 22, no 10-12, 1387-1398 p.Article in journal (Refereed) Published
Abstract [en]

Nuclear factor-κB (NF-κB) is responsible for the expression by regulating many genes for immune response, cell adhesion, differentiation, proliferation, angiogenesis and apoptosis. The function of NF-κB is inhibited by binding to NF-κB inhibitor (IκB), and imbalance of NF-κB and IκB has been associated with development of many diseases, including tumours. In this review, we focus on polymorphisms of the NFKB and NFKBI genes in relation to development of common inflammatory diseases including ulcerative colitis (UC), Crohn's disease (CD), rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis, giant cell arthritis, type 1 diabetes, multiple sclerosis, celiac disease, and Parkinson's disease, as well as susceptibility of several cancers, such as oral squamous cell carcinoma, colorectal cancer (CRC), hepatocellular carcinoma, breast cancer and myeloma.

Place, publisher, year, edition, pages
2007. Vol. 22, no 10-12, 1387-1398 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-40449Local ID: 53266OAI: oai:DiVA.org:liu-40449DiVA: diva2:261298
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-11

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Sun, Xiao-FengZhang, Hong

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Faculty of Health SciencesOncologyDepartment of Oncology UHLDivision of dermatology and venereology
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