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Bone mass, biochemical markers and growth in children with chronic kidney disease: A 1-year prospective study
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Division of clinical chemistry. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Chemistry.
2007 (English)In: Acta Paediatrica, ISSN 0803-5253, Vol. 96, no 5, 720-725 p.Article in journal (Refereed) Published
Abstract [en]

Aim: This study was designed to investigate bone mineral density (BMD), growth parameters and biochemical markers in children with chronic kidney disease (CKD). Methods: Sixteen patients, 4-18 years, with CKD were prospectively followed for 1 year. Auxological data, body composition, BMD by dual-energy X-ray absorptiometry, bone age, bone turnover markers, vitamin D, parathyroid hormone (PTH), leptin, osteoprotegerin, insulin-like growth factor-I (IGF-I) and IGF binding protein-3 were measured. A questionnaire regarding bone health and diet was also performed. Results: Delayed bone age was observed (n = 11) and the BMD Z-scores for total body were below zero in seven patients. However, total body BMD (TBBMD) increased in 12 patients. Most patients had increased osteocalcin and carboxy-terminal telopeptide of type I collagen, but normal alkaline phosphatase, type I procollagen intact amino-terminal propeptide and tartrate-resistant acid phosphatase 5b. Ten patients had increased PTH. Most children had normal levels of leptin, osteoprotegerin, IGF-I and IGFBP-3. Leptin, at baseline, correlated with differences in TBBMD over 1 year. Conclusions: Only seven (44%) had negative Z-scores and TBBMD increased over 1 year. Bone markers at baseline did not predict the longitudinal changes in BMD. © 2007 The Author(s).

Place, publisher, year, edition, pages
2007. Vol. 96, no 5, 720-725 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-40475DOI: 10.1111/j.1651-2227.2007.00236.xLocal ID: 53353OAI: diva2:261324
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-11

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Magnusson, Per
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Faculty of Health SciencesDivision of clinical chemistryDepartment of Clinical Chemistry
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