Abstract: The relationship of speech and gesture to meaning and mind has been viewed from various perspectives. In this paper I review some of these perspectives and conclude that speech and gesture should be viewed as complementary aspects of the on-going incremental determination of dialogic inter-subjective intentionality in communicative interaction. Speech and gesture relate brain with brain to enable meaning and mind. Life-world meaning is enacted through speech and gesture in interaction. Mind is viewed as embodied but distributed and as enacted in interaction. Mind and meaning reside in the field created by interacting brain-bodies. A multidisciplinary empirical research methodology for the study of speech and gesture in relation to mind and meaning in interaction is described and exemplified.