Bioinformatics processing of protein and transcript profiles of normal and transformed cell lines indicates functional impairment of transcriptional regulators in buccal carcinoma
2007 (English)In: Journal of Proteome Research, ISSN 1535-3893, E-ISSN 1535-3907, Vol. 6, no 9, 3705-3717 p.Article in journal (Refereed) Published
Normal and two transformed buccal keratinocyte lines were cultured under a standardized condition to explore mechanisms of carcinogenesis and tumor marker expression at transcript and protein levels. An approach combining three bioinformatic programs allowed coupling of abundant proteins and large-scale transcript data to low-abundance transcriptional regulators. The analysis identified previously proposed and suggested novel protein biomarkers, gene ontology categories, molecular networks, and functionally impaired key regulator genes for buccal/oral carcinoma. © 2007 American Chemical Society.
Place, publisher, year, edition, pages
American Chemical Society (ACS), 2007. Vol. 6, no 9, 3705-3717 p.
cancer biomarkers; proteomics; transcriptomics; oral cancer; gene ontology; molecular networks; transcription factors; cultured oral keratinocytes; serum-free conditions
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-40715DOI: 10.1021/pr070308qISI: 000249371000035PubMedID: 17696463Local ID: 53977OAI: oai:DiVA.org:liu-40715DiVA: diva2:261564