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Bioinformatics processing of protein and transcript profiles of normal and transformed cell lines indicates functional impairment of transcriptional regulators in buccal carcinoma
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
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2007 (English)In: Journal of Proteome Research, ISSN 1535-3893, E-ISSN 1535-3907, Vol. 6, no 9, 3705-3717 p.Article in journal (Refereed) Published
Abstract [en]

Normal and two transformed buccal keratinocyte lines were cultured under a standardized condition to explore mechanisms of carcinogenesis and tumor marker expression at transcript and protein levels. An approach combining three bioinformatic programs allowed coupling of abundant proteins and large-scale transcript data to low-abundance transcriptional regulators. The analysis identified previously proposed and suggested novel protein biomarkers, gene ontology categories, molecular networks, and functionally impaired key regulator genes for buccal/oral carcinoma. © 2007 American Chemical Society.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2007. Vol. 6, no 9, 3705-3717 p.
Keyword [en]
cancer biomarkers; proteomics; transcriptomics; oral cancer; gene ontology; molecular networks; transcription factors; cultured oral keratinocytes; serum-free conditions
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-40715DOI: 10.1021/pr070308qISI: 000249371000035PubMedID: 17696463Local ID: 53977OAI: oai:DiVA.org:liu-40715DiVA: diva2:261564
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13Bibliographically approved

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Roberg, Karin

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Oto-Rhiono-Laryngology and Head & Neck SurgeryFaculty of Health SciencesDepartment of ENT - Head and Neck Surgery UHL
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