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Addition of intravenous iron to epoetin beta increases hemoglobin response and decreases epoetin dose requirement in anemic patients with lymphoproliferative malignancies: A randomized multicenter study
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Oncology. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Haematology UHL.
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2007 (English)In: Leukemia, ISSN 0887-6924, Vol. 21, no 4, 627-632 p.Article in journal (Refereed) Published
Abstract [en]

This randomized study assessed if intravenous iron improves hemoglobin (Hb) response and permits decreased epoetin dose in anemic (Hb 9-11,11 g/dl), transfusion-independent patients with stainable iron in the bone marrow and lymphoproliferative malignancies not receiving chemotherapy. Patients (n=67) were randomized to subcutaneous epoetin beta 30 000 IU once weekly for 16 weeks with or without concomitant intravenous iron supplementation. There was a significantly (P25%) lower in the iron group, as was the total epoetin dose (P=0.051). In conclusion, the Hb increase and response rate were significantly greater with the addition of intravenous iron to epoetin treatment in iron-replete patients and a lower dose of epoetin was required.

Place, publisher, year, edition, pages
2007. Vol. 21, no 4, 627-632 p.
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Medical and Health Sciences
URN: urn:nbn:se:liu:diva-40746DOI: 10.1038/sj.leu.2404562Local ID: 54027OAI: diva2:261595
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-11

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Ahlberg, Lucia
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Faculty of Health SciencesOncologyDepartment of Haematology UHL
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