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Serum concentration of interleukin-18 is up-regulated in patients with ANCA-associated vasculitis
Klin Immunol Göteborg.
Klin Immunol Göteborg.
Klin Immunol Göteborg.
Linköping University, Department of Medical and Health Sciences, Nephrology. Linköping University, Faculty of Health Sciences. (Landstinget i Östergötland; Local Health Care Services in Central Östergötland; Department of Nephrology; Närsjukvården i centrala Östergötland; Njurmedicinska kliniken)
2007 (English)In: Autoimmunity, ISSN 0891-6934, Vol. 40, no 7, 529-531 p.Article in journal (Refereed) Published
Abstract [en]

We investigated circulating interleukin-18 concentrations in patients with ANCA-associated vasculitis (ASV) and healthy control subjects, and included a group of hemodialysis patients, a patient group previously reported to show high IL-18 plasma levels. Anti-proteinase 3 (PR3) and anti-myeloperoxidase (MPO) serum levels were also measured. Interestingly we found significantly increased serum IL-18 concentrations in ASV patients as compared to healthy controls, 437 vs. 185 pg/ml (p < 0.0001). The increase of IL-18 production was similar irrespective of presence of autoantibodies to PR3 or MPO. As expected the hemodialysis patients also showed significantly increased circulating IL-18 concentrations as compared to control subjects.

Place, publisher, year, edition, pages
2007. Vol. 40, no 7, 529-531 p.
Keyword [en]
ANCA, Wegener's granulomatosis, interleukin-18, vasculitis
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-40757DOI: 10.1080/08916930701622783Local ID: 54054OAI: diva2:261606
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2014-01-15Bibliographically approved

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