Active cytomegalovirus replication in patients with coronary disease
2007 (English)In: Scandinavian Cardiovascular Journal, ISSN 1401-7431, Vol. 41, no 4, 230-234 p.Article in journal (Refereed) Published
Objectives. To study the prevalence of active cytomegalovirus (CMV) infection in patients with stable and unstable conditions of coronary artery disease (CAD). Design. Forty patients with acute coronary syndrome (ACS), 50 patients with stable angina and angiographically verified CAD (SA) and 50 clinically healthy controls were included. Monocytes were isolated from peripheral blood and CMV-RNA expression was determined by a nested RT-PCR assay. CMV IgM and IgG antibodies, interleukin-(IL)-6, IL-10 and CRP were measured in serum. Results. The prevalence of active CMV infection was significantly higher in patients with ACS (15%) and in patients with SA (10%) compared with controls (2%) (p < 0.001). The presence of an active CMV infection was associated with increased serum concentrations of IL-6. Conclusions. Active CMV infection was found to a larger extent in CAD patients than in healthy controls. The data indicate that CAD patients are more susceptible to reactivation of CMV and put new focus on the role of CMV in atherosclerosis.
Place, publisher, year, edition, pages
2007. Vol. 41, no 4, 230-234 p.
cytomegalovirus, monocytes, coronary artery disease, acute coronary syndrome
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-40759DOI: 10.1080/14017430701383755Local ID: 54057OAI: oai:DiVA.org:liu-40759DiVA: diva2:261608