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Active cytomegalovirus replication in patients with coronary disease
Karolinska Institutet.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Cardiology. Östergötlands Läns Landsting, Heart Centre, Department of Cardiology.
Karilinska Institutet.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Clinical Immunology. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Immunology and Transfusion Medicine.
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2007 (English)In: Scandinavian Cardiovascular Journal, ISSN 1401-7431, Vol. 41, no 4, 230-234 p.Article in journal (Refereed) Published
Abstract [en]

Objectives. To study the prevalence of active cytomegalovirus (CMV) infection in patients with stable and unstable conditions of coronary artery disease (CAD). Design. Forty patients with acute coronary syndrome (ACS), 50 patients with stable angina and angiographically verified CAD (SA) and 50 clinically healthy controls were included. Monocytes were isolated from peripheral blood and CMV-RNA expression was determined by a nested RT-PCR assay. CMV IgM and IgG antibodies, interleukin-(IL)-6, IL-10 and CRP were measured in serum. Results. The prevalence of active CMV infection was significantly higher in patients with ACS (15%) and in patients with SA (10%) compared with controls (2%) (p < 0.001). The presence of an active CMV infection was associated with increased serum concentrations of IL-6. Conclusions. Active CMV infection was found to a larger extent in CAD patients than in healthy controls. The data indicate that CAD patients are more susceptible to reactivation of CMV and put new focus on the role of CMV in atherosclerosis.

Place, publisher, year, edition, pages
2007. Vol. 41, no 4, 230-234 p.
Keyword [en]
cytomegalovirus, monocytes, coronary artery disease, acute coronary syndrome
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-40759DOI: 10.1080/14017430701383755Local ID: 54057OAI: oai:DiVA.org:liu-40759DiVA: diva2:261608
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-11

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Jonasson, LenaErnerudh, Jan

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Jonasson, LenaErnerudh, Jan
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Faculty of Health SciencesCardiologyDepartment of CardiologyClinical ImmunologyDepartment of Clinical Immunology and Transfusion Medicine
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