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Effects of inhibitors of the arachidonic acid cascade on primary muscle culture from a Duchenne muscular dystrophy patient
Linköping University, Department of Neuroscience and Locomotion, Neurology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Neuroscience and Locomotion, Neurology. Linköping University, Faculty of Health Sciences.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Clinical Immunology. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Immunology and Transfusion Medicine.
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2007 (English)In: Prostaglandins, Leukotrienes and Essential Fatty Acids, ISSN 0952-3278, E-ISSN 1532-2823, Vol. 77, no 3-4, 217-223 p.Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to elucidate the mechanisms of action for potential targets of therapeutic intervention related to the arachidonic acid cascade in muscular dystrophy. Primary cultures from a Duchenne patient were used to study the expression of dystrophin-1, utrophin, desmin, neonatal myosin heavy chain (MHCn) and Bcl-2 during inhibition of phospholipase A2 (PLA2), cyclooxygenase (COX) and lipoxygenase (LOX). Hypo-osmotic treatment was applied in order to trigger Ca2+ influx and PLA2 activity. Inhibition of PLA2 and LOX with prednisolone and nordihydroguaiaretic acid (NDGA) caused a semi-quantitative increase of utrophin and Bcl-2-, and a dose-dependent, quantitative increase of desmin expression, an effect that was augmented by hypo-osmotic treatment. Our results indicate that LOX inhibitors, similarly to corticosteroids, can be beneficial in the treatment of muscular dystrophies. © 2007 Elsevier Ltd. All rights reserved.

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2007. Vol. 77, no 3-4, 217-223 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-40845DOI: 10.1016/j.plefa.2007.10.002Local ID: 54297OAI: oai:DiVA.org:liu-40845DiVA: diva2:261694
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-08-30

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Gati, IstvanDanielsson, OlofErnerudh, JanÖllinger, KarinDizdar-Segrell, Nil

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Gati, IstvanDanielsson, OlofErnerudh, JanÖllinger, KarinDizdar-Segrell, Nil
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NeurologyFaculty of Health SciencesClinical ImmunologyDepartment of Clinical Immunology and Transfusion MedicinePathologyDepartment of Clinical Pathology and Clinical GeneticsDepartment of Neurology
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Prostaglandins, Leukotrienes and Essential Fatty Acids
Medical and Health Sciences

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