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Bioprocess control from a multivariate process trajectory.
Novozymes Biopharma AB.
Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Biotechnology .
2004 (English)Article in journal (Refereed) Published
Abstract [en]

A multivariate bioprocess control approach, capable of tracking a pre-set process trajectory correlated to the biomass or product concentration in the bioprocess is described. The trajectory was either a latent variable derived from multivariate statistical process monitoring (MSPC) based on partial least squares (PLS) modeling, or the absolute value of the process variable. In the control algorithm the substrate feed pump rate was calculated from on-line analyzer data. The only parameters needed were the substrate feed concentration and the substrate yield of the growth-limiting substrate. On-line near-infrared spectroscopy data were used to demonstrate the performance of the control algorithm on an Escherichia coli fed-batch cultivation for tryptophan production. The controller showed good ability to track a defined biomass trajectory during varying process dynamics. The robustness of the control was high, despite significant external disturbances on the cultivation and control parameters.

Place, publisher, year, edition, pages
2004. Vol. 26, no 6, 401-411 p.
National Category
Natural Sciences
URN: urn:nbn:se:liu:diva-40927Local ID: 54656OAI: diva2:261776
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-12

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Mandenius, Carl-Fredrik
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The Institute of TechnologyBiotechnology
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