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In vivo cytokine secretion and NF-κB activation around titanium and copper implants
Dept. of Biomaterials, Inst. of Surgical Sciences Sahlgrenska Academy at Göteborg University.
Dept. of Biomaterials, Inst. of Surgical Sciences Sahlgrenska Academy at Göteborg University.
Dept. of Biomaterials, Inst. of Surgical Sciences Sahlgrenska Academy at Göteborg University.
Dept. of Biomaterials, Inst. of Surgical Sciences Sahlgrenska Academy att Göteborg University.
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2005 (English)In: Biomaterials, ISSN 0142-9612, E-ISSN 1878-5905, Vol. 26, no 5, 519-527 p.Article in journal (Refereed) Published
Abstract [en]

The early biological response at titanium (Ti), copper (Cu)-coated Ti and sham sites was evaluated in an in vivo rat model. Material surface chemical and topographical properties were characterized using Auger electron spectroscopy, energy dispersive X-ray spectroscopy and interferometry, respectively. The number of leukocytes, cell types and cell viability (release of lactate dehydrogenase) were determined in the implant-interface exudate. The contents of activated nuclear transcription factor NF-κB, interleukin-6 (IL-6) and interleukin-10 (IL-10) were determined by enzyme linked immunosorbent assay. An increase in the number of leukocytes, in particular, polymorphonuclear leukocytes, was observed between 12 and 48h around Cu. A marked decrease of exudate cell viability was found around Cu after 48h. The total amounts of activated NF-κB after 12h was highest in Ti exudates whereas after 48h the highest amount of NF-κB was detected around Cu. The levels of cytokine IL-6 were consistently high around Cu at both time periods. No differences in IL-10 contents were detected, irrespective of material/sham and time. The results show that materials with different toxicity grades (titanium with low and copper with high toxicity) exhibit early differences in the activation of NF-κB, extracellular expression and secretion of mediators, causing major differences in inflammatory cell accumulation and death in vivo. © 2004 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
2005. Vol. 26, no 5, 519-527 p.
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Natural Sciences
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URN: urn:nbn:se:liu:diva-41173DOI: 10.1016/j.biomaterials.2004.02.066Local ID: 55297OAI: oai:DiVA.org:liu-41173DiVA: diva2:262024
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13

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Tengvall, Pentti

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