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Is the unfolded state the Rosetta Stone of the protein folding problem?
Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Biochemistry.
Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Biochemistry.
2000 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 276, no 2, 393-398 p.Article in journal (Refereed) Published
Abstract [en]

Solving the protein folding problem is one of the most challenging tasks in the post genomic era. Identification of folding-initiation sites is very important in order to understand the protein folding mechanism. Detection of residual structure in unfolded proteins can yield important clues to the initiation sites in protein folding. A substantial number of studied proteins possess residual structure in hydrophobic regions clustered together in the protein core. These stable structures can work as seeds in the folding process. In addition, local preferences for secondary structure in the form of turns for ▀-sheet initiation and helical turns for a-helix formation can guide the folding reaction. In this respect the unfolded states, studied at increasing structural resolution, can be the Rosetta Stone of the protein folding problem. (C) 2000 Academic Press.

Place, publisher, year, edition, pages
2000. Vol. 276, no 2, 393-398 p.
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Natural Sciences
Identifiers
URN: urn:nbn:se:liu:diva-42082DOI: 10.1006/bbrc.2000.3360Local ID: 60253OAI: oai:DiVA.org:liu-42082DiVA: diva2:262937
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13

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Hammarström, PerCarlsson, Uno

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