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Expression of PINCH protein in gliomas and its clinicopathological significance
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2007 (English)In: Oncology, ISSN 0890-9091, Vol. 72, no 5-6, 343-346 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: Particularly interesting new cysteine-histidine-rich protein (PINCH), as a LIM domain adapter protein, functions in the integrin and growth factor signal transduction pathway, and is upregulated in tumor-associated stroma in several types of cancers. However, no study of PINCH has been carried out in gliomas, therefore we examined PINCH expression in gliomas and its clinicopathological significance. Methods: PINCH expression was immunohistochemically examined in 82 gliomas, along with 26 matched adjacent normal brain samples and 10 recurred gliomas. Results: PINCH was strongly expressed in the primary (35%, p = 0.0001) or recurred tumors (40%, p = 0.004) and weak in normal brain tissue. PINCH expression was significantly increased in high-grade gliomas (55 vs. 24%, high- vs. low-grade gliomas, p = 0.004). There was no association of PINCH expression with gender, age, tumor number, size, histological type and tumor location (p > 0.05). Conclusions: PINCH expression may be involved in glioma development and differentiation. Copyright © 2008 S. Karger AG.

Place, publisher, year, edition, pages
2007. Vol. 72, no 5-6, 343-346 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-42241DOI: 10.1159/000113064Local ID: 61708OAI: diva2:263097
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-11

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Sun, Xiao-Feng
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Faculty of Health SciencesOncologyDepartment of Oncology UHL
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