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In vitro effects of antipsychotics on human platelet adhesion and aggregation and plasma coagulation
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Clinical Pharmacology. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Pharmacology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Pharmacology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Division of clinical chemistry. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Chemistry.
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2007 (English)In: Clinical and experimental pharmacology & physiology, ISSN 0305-1870, E-ISSN 1440-1681, Vol. 34, no 8, 775-780 p.Article in journal (Refereed) Published
Abstract [en]

1. Several studies suggest an association between venous thromboembolism and the use of antipsychotic drugs, especially clozapine, but the biological mechanisms are unknown. It has been suggested that antipsychotic drugs enhance aggregation of platelets and thereby increase the risk of venous thrombosis. The purpose of the present study was to examine the effects of clozapine and its main metabolite, N-desmethyl clozapine, as well as olanzapine, risperidone and haloperidol, on platelet adhesion and aggregation and on plasma coagulation in vitro. 2. Blood was collected from healthy subjects free of medication. Platelet adhesion to different protein surfaces and aggregation were measured in microplates. The coagulation methods of activated partial thromboplastin time (APTT) and prothrombin time were performed in platelet-poor plasma. 3. Clozapine was the only compound that increased platelet adhesion and aggregation and shortened APTT. The effect appeared at therapeutic concentrations and was significant but weak. 4. This weak effect of clozapine on haemostasis may explain, in part, the association of this compound and venous thromboembolism. © 2007 The Authors.

Place, publisher, year, edition, pages
2007. Vol. 34, no 8, 775-780 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-42242DOI: 10.1111/j.1440-1681.2007.04650.xLocal ID: 61733OAI: oai:DiVA.org:liu-42242DiVA: diva2:263098
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2013-09-03Bibliographically approved

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Hägg, StaffanEriksson, AndreasLindahl, TomasWhiss, Per A
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Faculty of Health SciencesClinical PharmacologyDepartment of Clinical PharmacologyPharmacologyDivision of clinical chemistryDepartment of Clinical Chemistry
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Clinical and experimental pharmacology & physiology
Medical and Health Sciences

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