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IgA endomysium antibodies: an early predictor for celiac disease in children without villous atrophy
Östergötlands Läns Landsting, Local Health Care Services in the West of Östergötland, Unit of Research and Development in Local Health Care, County of Östergötland. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Pediatrics. Linköping University, Faculty of Health Sciences.
Norrköping Hospital, Norrköping, Sweden.
Motala Hospital, Motala, Sweden.
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2008 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 97, no 7, 972-976 p.Article in journal (Refereed) Published
Abstract [en]

Aim: To evaluate possible differences between children with anti-endomysium antibodies (EMA) positivity and normal small bowel mucosa and children with positive EMA and an enteropathy diagnosed as celiac disease (CD).

Methods: Children with suspected CD and positive EMA (≥1/10) undergoing small bowel biopsy during 1996 to 2002, were investigated (n = 133). Data registered were: year and month of birth, timing of the first biopsy, sex, heredity for CD, dermatitis herpetiformis and diabetes mellitus and outcome of the anti-gliadin antibody test (AGA). The case group, with EMA positivity and normal histology (n = 39; 59% female, mean age at the first biopsy 7.3 years, range 1.4–16), was compared with the disease control group, with positive EMA and a biopsy suggestive and further on diagnosed as CD (n = 94; 56% female; mean age 7.6 years at the first biopsy, range 0.70–17).

Results: AGA positivity and heredity for CD were found to predict the outcome of a pathological jejunal mucosa. Nineteen of the 39 children in the case group were rebiopsied of whom 11 had developed an enteropathy during a follow-up period of 2–7 years (median 4.5 years).

Conclusions: EMA positivity in the absence of small bowel enteropathy could be a very early predictor for later overt CD, and necessitates further follow-up, especially if the child is AGA positive and there is a family history of CD.

Place, publisher, year, edition, pages
2008. Vol. 97, no 7, 972-976 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-42701DOI: 10.1111/j.1651-2227.2008.00881.xLocal ID: 68300OAI: diva2:263558
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2012-09-21Bibliographically approved

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Grodzinsky, EwaFälth-Magnusson, KarinHögberg, LottaLaurin, PiaStenhammar, Lars
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Unit of Research and Development in Local Health Care, County of ÖstergötlandFaculty of Health SciencesPediatrics
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Acta Paediatrica
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