Wild-type Leishmania donovani promastigotes block maturation, increase integrin expression and inhibit detachment of human monocyte-derived dendritic cells - The influence of phosphoglycans
2008 (English)In: FEMS Microbiology Letters, ISSN 0378-1097, Vol. 279, no 1, 92-102 p.Article in journal (Refereed) Published
The protective immune response against the parasite, including the role of dendritic cells (DC) in the course of infection, plays a fundamental role. This study shows that wild-type (WT) Leishmania promastigotes and specifically the phosphoglycans family of virulence-associated antigens inhibit human monocyte-derived dendritic cells (MoDC) maturation and detachment to distinct surfaces. Immature phagocytosis of Leishmania donovani promastigotes by immature MoDC results in the increased expression of CD11b and CD51, and inhibition of cell detachment to distinct surfaces, which was dependent on the presence of phosphoglycans. These findings demonstrate that phosphoglycans of WT L. donovani might also inhibit human DC migration to lymphoid organs. © 2007 Federation of European Microbiological Societies.
Place, publisher, year, edition, pages
2008. Vol. 279, no 1, 92-102 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-43422DOI: 10.1111/j.1574-6968.2007.01013.xLocal ID: 73822OAI: oai:DiVA.org:liu-43422DiVA: diva2:264281