A case report of plasmapheresis treatment in a patient with paraneoplastic cerebellar degeneration and high anti-Yo antibody titers
2008 (English)In: Therapeutic Apheresis and Dialysis, ISSN 1744-9979, Vol. 12, no 1, 82-85 p.Article in journal (Refereed) Published
A patient with paraneoplastic cerebellar degeneration due to anti-Purkinje cell antibodies (anti-Yo) arising from ovarian carcinoma with metastases was treated with three plasmapheresis (PP) series (a total of 22 PP treatments) over one year and was monitored by repeated otoneurological testing, balance tests and clinical investigations. Blood samples for antibody titers were checked on several occasions. Initially there was a weak clinical response and significantly improved test results regarding the caloric response, as well as a possible effect on visual suppression of the vestibulo-ocular reflex after caloric ear irrigation. After the first series of PP treatment, new metastases were found. A half year later there was a progressive course with increasing general symptoms. Serology tests showed continuously high titers of anti-Yo antibody, although somewhat lower after PP. We thus report a minor and short-lived effect of PP, possibly inhibited by the natural course of metastatic disease. © 2008 International Society for Apheresis.
Place, publisher, year, edition, pages
2008. Vol. 12, no 1, 82-85 p.
Autoantibodies/*blood Female Humans Middle Aged Neoplasm Metastasis/immunology Ovarian Neoplasms/complications Paraneoplastic Cerebellar Degeneration/immunology/*therapy *Plasmapheresis Purkinje Cells/immunology
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-43446DOI: 10.1111/j.1744-9987.2007.00546.xLocal ID: 73879OAI: oai:DiVA.org:liu-43446DiVA: diva2:264305