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A case report of plasmapheresis treatment in a patient with paraneoplastic cerebellar degeneration and high anti-Yo antibody titers
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Neurology . Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Oto-Rhiono-Laryngology and Head & Neck Surgery . Östergötlands Läns Landsting, Reconstruction Centre, Department of ENT - Head and Neck Surgery UHL.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Immunology and Transfusion Medicine.
2008 (English)In: Therapeutic Apheresis and Dialysis, ISSN 1744-9979, Vol. 12, no 1, 82-85 p.Article in journal (Refereed) Published
Abstract [en]

A patient with paraneoplastic cerebellar degeneration due to anti-Purkinje cell antibodies (anti-Yo) arising from ovarian carcinoma with metastases was treated with three plasmapheresis (PP) series (a total of 22 PP treatments) over one year and was monitored by repeated otoneurological testing, balance tests and clinical investigations. Blood samples for antibody titers were checked on several occasions. Initially there was a weak clinical response and significantly improved test results regarding the caloric response, as well as a possible effect on visual suppression of the vestibulo-ocular reflex after caloric ear irrigation. After the first series of PP treatment, new metastases were found. A half year later there was a progressive course with increasing general symptoms. Serology tests showed continuously high titers of anti-Yo antibody, although somewhat lower after PP. We thus report a minor and short-lived effect of PP, possibly inhibited by the natural course of metastatic disease. © 2008 International Society for Apheresis.

Place, publisher, year, edition, pages
2008. Vol. 12, no 1, 82-85 p.
Keyword [en]
Autoantibodies/*blood Female Humans Middle Aged Neoplasm Metastasis/immunology Ovarian Neoplasms/complications Paraneoplastic Cerebellar Degeneration/immunology/*therapy *Plasmapheresis Purkinje Cells/immunology
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-43446DOI: 10.1111/j.1744-9987.2007.00546.xLocal ID: 73879OAI: oai:DiVA.org:liu-43446DiVA: diva2:264305
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-10

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Landtblom, Anne-MarieLindvall, BjörnLedin, TorbjörnBerlin, Gösta

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Faculty of Health SciencesDepartment of Clinical and Experimental MedicineDepartment of NeurologyNeurology Oto-Rhiono-Laryngology and Head & Neck Surgery Department of ENT - Head and Neck Surgery UHLDepartment of Clinical Immunology and Transfusion Medicine
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