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The role of microbiota and probiotics in stress-induced gastrointestinal damage
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Surgery . Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Surgery in Östergötland.
2008 (English)In: Current molecular medicine, ISSN 1566-5240, Vol. 8, no 4, 282-298 p.Article in journal (Refereed) Published
Abstract [en]

Stress has a major impact on gut physiology and may affect the clinical course of gastro-intestinal diseases. In this review, we focus on the interaction between commensal gut microbiota and intestinal mucosa during stress and discuss the possibilities to counteract the deleterious effects of stress with probiotics. Normally, commensal microbes and their hosts benefit from a symbiotic relationship. Stress does, however, reduce the number of Lactobacilli, while on the contrary, an increased growth, epithelial adherence and mucosal uptake of gram-negative pathogens, e.g. E. coli and Pseudomonas, are seen. Moreover, intestinal bacteria have the ability to sense a stressed host and up-regulate their virulence factors when opportunity knocks. Probiotics are "live microorganisms which, when administered in adequate amounts, confer a health benefit on the host", and mainly represented by Lactic Acid Bacteria. Probiotics can counteract stress-induced changes in intestinal barrier function, visceral sensitivity and gut motility. These effects are strain specific and mediated by direct bacterial-host cell interaction and/or via soluble factors. Mechanisms of action include competition with pathogens for essential nutrients, induction of epithelial heat-shock proteins, restoring of tight junction protein structure, up-regulation of mucin genes, secretion of defensins, and regulation of the NFκB signalling pathway. In addition, the reduction of intestinal pain perception was shown to be mediated via cannabinoid receptors. Based on the studies reviewed here there is clearly a rationale for probiotic treatment in patients with stress-related intestinal disorders. We are however far from being able to choose the precise combination of strains or bacterial components for each clinical setting. © 2008 Bentham Science Publishers Ltd.

Place, publisher, year, edition, pages
2008. Vol. 8, no 4, 282-298 p.
Keyword [en]
Animals Critical Illness Enteritis/etiology/immunology/physiopathology/*therapy Humans Immunologic Factors/*pharmacology/therapeutic use Intestinal Mucosa/*microbiology Intestines/*microbiology/physiopathology Probiotics/*pharmacology/therapeutic use Stre
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-43450DOI: 10.2174/156652408784533779Local ID: 73883OAI: diva2:264309
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-10

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Lutgendorff, FemkeSöderholm, Johan D
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Faculty of Health SciencesDepartment of Clinical and Experimental MedicineSurgery Department of Surgery in Östergötland
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