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Longitudinal study of the maternal insulin-like growth factor system before, during and after pregnancy in relation to fetal and infant weight
Linköping University, Department of Clinical and Experimental Medicine, Nutrition. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Nutrition. Linköping University, Faculty of Health Sciences.
Unit for Endocrinology and Diabetes, Karolinska Institutet, Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.
Unit for Endocrinology and Diabetes, Karolinska Institutet, Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.
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2008 (English)In: Hormone Research, ISSN 0301-0163, E-ISSN 1423-0046, Vol. 69, no 2, 99-106 p.Article in journal (Refereed) Published
Abstract [en]

Background: The maternal insulin-like growth factor (IGF) system is considered to be involved in fetal growth regulation. However, available data linking this system to fetal growth are contradictory and incomplete.

Aims: To measure components of the IGF system before, during and after pregnancy in healthy women and to relate these results, and their changes during pregnancy, to fetal weight (gestational week 31) and birth weight.

Methods: Serum concentrations of IGF-I, IGF-II, IGF-binding protein (IGFBP)-1, IGFBP-3 and IGFBP-3 protease activity were assessed in 23 women before conception, at weeks 8, 14, 20, 32 and 35 of pregnancy and 2 weeks postpartum. The data were analyzed using simple and multiple linear regression.

Results: One third of the variability in fetal weight was explained by IGF-I in combination with IGFBP-3 protease activity, both assessed at gestational week 32 (p = 0.013). Birth weight was negatively correlated (r = –0.43 to –0.59) with IGFBP-1 at gestational week 20 (p = 0.041), 32 (p = 0.012) and 35 (p = 0.003).

Conclusion: We propose there is a finely tuned balance among the components of the IGF system, providing a means for fetal growth regulation.

Place, publisher, year, edition, pages
2008. Vol. 69, no 2, 99-106 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-43452DOI: 10.1159/000111813Local ID: 73887OAI: oai:DiVA.org:liu-43452DiVA: diva2:264311
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13

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Olausson, HannaLöf, MarieForsum, ElisabetSohlström, Annica

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