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TNF-α and IL-10 gene polymorphisms versus cardioimmunological responses in sudden infant death
Linköping University, Department of Clinical and Experimental Medicine, Forensic Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Forensic Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Forensic Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Forensic Genetics. Linköping University, Faculty of Health Sciences.
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2008 (English)In: Fetal & Pediatric Pathology, ISSN 1551-3815, Vol. 27, no 3, 149-165 p.Article in journal (Refereed) Published
Abstract [en]

We hypothesized that genetic variations of cytokines could contribute to the risk of developing a fatal immunological reaction in the heart of infants. Thus, tumor necrosis factor (TNF)-α and interleukin (IL)-10 gene polymorphisms versus induction of cardioimmunologxical responses in victims of sudden infant death syndrome (SIDS) were explored. We genotyped 35 infants (23 cases of SIDS and 12 infants with a known cause of death), and 100 healthy adult controls for IL-10 –1082 G/A, −592 C/A and TNF-α-238 G/A, −308 G/A. We found a higher frequency of the ATA haplotype and ATA/ATA genotype of IL-10 associated with SIDS (13%). The frequency of homozygote infants for IL-10 haplotypes in SIDS was higher (52%) than the control group (34%). All SIDS cases were homozygotice for the TNF-α-238 G allele and 20 infants were homozygous for the TNF-α-308 G allele in the same group. None of the infants with higher levels of infiltrated T-cells (n=8) was homozygous for IL-10 gene polymorphisms, whereas in contrast 3 cases of the 6 that displayed higher levels of cardiac mast cells were homozygous. In this study, the increased number of interstitial T-cells, mast cells, and macrophages in the myocardial interstitium demonstrated no correlation with the genotype for either cytokines.

Place, publisher, year, edition, pages
2008. Vol. 27, no 3, 149-165 p.
Keyword [en]
cytokines, gene polymorphism, myocardium, immunological competent cells, SIDS
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-43454DOI: 10.1080/15513810802077651Local ID: 73889OAI: oai:DiVA.org:liu-43454DiVA: diva2:264313
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2014-03-10Bibliographically approved

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Perskvist, NasrinSkoglund, KarinEdston, ErikBäckström, Gerd

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