TNF-α and IL-10 gene polymorphisms versus cardioimmunological responses in sudden infant death
2008 (English)In: Fetal & Pediatric Pathology, ISSN 1551-3815, Vol. 27, no 3, 149-165 p.Article in journal (Refereed) Published
We hypothesized that genetic variations of cytokines could contribute to the risk of developing a fatal immunological reaction in the heart of infants. Thus, tumor necrosis factor (TNF)-α and interleukin (IL)-10 gene polymorphisms versus induction of cardioimmunologxical responses in victims of sudden infant death syndrome (SIDS) were explored. We genotyped 35 infants (23 cases of SIDS and 12 infants with a known cause of death), and 100 healthy adult controls for IL-10 –1082 G/A, −592 C/A and TNF-α-238 G/A, −308 G/A. We found a higher frequency of the ATA haplotype and ATA/ATA genotype of IL-10 associated with SIDS (13%). The frequency of homozygote infants for IL-10 haplotypes in SIDS was higher (52%) than the control group (34%). All SIDS cases were homozygotice for the TNF-α-238 G allele and 20 infants were homozygous for the TNF-α-308 G allele in the same group. None of the infants with higher levels of infiltrated T-cells (n=8) was homozygous for IL-10 gene polymorphisms, whereas in contrast 3 cases of the 6 that displayed higher levels of cardiac mast cells were homozygous. In this study, the increased number of interstitial T-cells, mast cells, and macrophages in the myocardial interstitium demonstrated no correlation with the genotype for either cytokines.
Place, publisher, year, edition, pages
2008. Vol. 27, no 3, 149-165 p.
cytokines, gene polymorphism, myocardium, immunological competent cells, SIDS
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-43454DOI: 10.1080/15513810802077651Local ID: 73889OAI: oai:DiVA.org:liu-43454DiVA: diva2:264313