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Serum amino acid profile in patients with acute pancreatitis
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Surgery . Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Surgery in Östergötland.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Surgery .
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Surgery . Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Surgery in Östergötland.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Medical Microbiology .
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2008 (English)In: Amino Acids, ISSN 0939-4451, E-ISSN 1438-2199, Vol. 35, no 1, 225-231 p.Article in journal (Refereed) Published
Abstract [en]

Patients in the early phase of acute pancreatitis (AP) have reduced serum levels of arginine and citrulline. This may be of patho-biological importance, since arginine is the substrate for nitric oxide, which in turn is involved in normal pancreatic physiology and in the inflammatory process. Serum amino acid spectrum was measured daily for five days and after recovery six weeks later in 19 patients admitted to the hospital for acute pancreatitis. These patients had abnormal levels of most amino acids including arginine, citrulline, glutamine and glutamate. Phenylalanine and glutamate were increased, while arginine, citrulline, ornithine and glutamine were decreased compared to levels after recovery. NO2/NO3 concentration in the urine, but not serum arginase activity, was significantly increased day 1 compared to day 5 after admission. Acute pancreatitis causes a disturbance of the serum amino acid spectrum, with possible implications for the inflammatory process and organ function both in the pancreas and the gut. Supplementation of selected amino acids could possibly be of value in this severe condition. © 2007 Springer-Verlag.

Place, publisher, year, edition, pages
2008. Vol. 35, no 1, 225-231 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-43458DOI: 10.1007/s00726-007-0557-5Local ID: 73897OAI: oai:DiVA.org:liu-43458DiVA: diva2:264317
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13

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Sandström, PerTrulsson, LenaGasslander, ThomasSundqvist, TommySvanvik, Joar

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